C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07B 61/00 (2006.01) C12M 1/00 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2346989
The present invention describes templated combinatorial chemical libraries comprised of a plurality of bifunctional molecules having both a chemical compound and a nucleic acid tag that defines the structure of the chemical compound and directs its synthesis. Also described are methods for producing, enriching and in vitro evolution of the bifunctional molecules of such libraries based on the nucleic acid tags and methods for selecting for library compounds having a desired activity.
La présente invention concerne des bibliothèques de chimie combinatoire à matrice d'ADN constituées d'une pluralité de molécules bifonctionnelles présentant, outre un composé chimique, un fragment d'acide nucléique qui définit la structure du composé chimique et dirige sa synthèse. L'invention concerne également des procédés mettant en oeuvre de tels fragments d'acide nucléique pour produire, enrichir et développer in vitro les molécules bifonctionnelles desdites bibliothèques. L'invention concerne en outre des procédés de sélection de bibliothèques de composés ayant une activité désirée.
Halpin David R.
Harbury Pehr B.
Gowling Lafleur Henderson Llp
The Board Of Trustees Of The Leland Stanford Junior University
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