Dna vaccination for treatment of autoimmune disease

Details Dna vaccination for treatment of autoimmune disease Dna vaccination for treatment of autoimmune disease

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2363269

A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treated by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-.gamma. and IL-15, are reduced.

On élimine de manière spécifique une réponse de cellules T pro-inflammatoires en injectant à un récepteur de l'ADN codant pour un autoantigène associé à une maladie auto-immune. On peut aussi traiter le récepteur par co-vaccination avec de l'ADN codant pour une cytokine Th2, en particulier codant pour IL4. En réponse à la vaccination, la prolifération de cellules T réactives à l'autoantigène et la sécrétion de cytokines Th1, y compris IL-2, IFN-.gamma. et IL-15 sont réduites.

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