A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2477406
A DNA vaccine effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor protein. This invention provides DNA vaccines that encode VEGF receptor-2 (KDR, SEQ ID NO: 2), VEGF receptor-1 (Flt-1, (SEQ ID NO: 4), or Flk-1 (the murine homolog of KDR, SEQ ID NO: 6), DNA sequences SEQ ID NOS: 1, 3, and 5 respectively, as well as methods of using such a DNA vaccine to inhibit vascular endothelial cell proliferation in the tumor micro- environment. Anti-angiogenesis and subsequent decrease in tumor growth and dissemination is achieved.
L'invention concerne un vaccin à ADN inhibant efficacement la prolifération de cellules endothéliales comprenant une construction d'ADN codant, de façon opératoire, pour une protéine du récepteur du facteur de croissance endothélial vasculaire (VEGF). Elle concerne des vaccins à ADN qui codent pour le récepteur 2 du VEGF (KDR, SEQ ID NO: 2), le récepteur 1 du VEGF (Flt-1, (SEQ ID NO: 4), ou Flk-1 (l'homologue murin de KDR, SEQ ID NO: 6), des séquences d'ADN, respectivement SEQ ID NOS: 1, 3, and 5, ainsi que des méthodes d'utilisation de tels vaccins à ADN afin d'inhiber la prolifération de cellules endothéliales vasculaires dans un micro-environnement tumoral. Il en résulte un effet anti-angiogénèse, une diminution de la croissance tumorale et de la dissémination.
Niethammer Andreas G.
Reisfeld Ralph A.
Xiang Rong
Cassan Maclean
The Scripps Research Institute
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