Dna vaccine expressing ha1 of equine-2 influenza virus

Details Dna vaccine expressing ha1 of equine-2 influenza virus Dna vaccine expressing ha1 of equine-2 influenza virus

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 31/7088 (2006.01) A61K 39/39 (2006.01) A61P 31/16 (2006.01)

Patent

CA 2523676

The invention is for a DNA vaccine expressing the hemagglutinin (HA1) gene of equine-2 influenza virus. By engineering a stop codon within HA1, expression of HA1 is ensured. By encapsulation of the DNA vaccine in liposome and by intranasal inoculation, it is sufficient to elicit protective immunity at a significantly lower dosage compared to a DNA vaccine expressing the full length HA gene. Lower dosage reduces the risk of induction of anti-DNA antibodies. Intranasal inoculation directly to the respiratory epithelial cells reduces the risk of DNA integration. The inventive vaccine is advantageous over current inactivated or live attenuated vaccines, as updating of the vaccine requires only the replacement of the encoding sequence with the new virus.

L'invention concerne un vaccin à ADN exprimant le gène de l'hémagglutinine (HA1) du virus grippal équin 2. Par la mise au point d'un codon d'arrêt à l'intérieur de HA1, l'expression de HA1 est assurée. Par l'encapsulation du vaccin à ADN dans un liposome et par inoculation intranasale, il est suffisant de mettre en lumière une immunité protectrice à un dosage significativement inférieur comparé à un vaccin à ADN exprimant le gène HA de longueur totale. Un dosage inférieur réduit le risque d'induction d'anticorps anti-ADN. L'inoculation intranasale directement dans les cellules hépitéliales respiratoires réduit le risque d'intégration d'ADN. Le vaccin de l'invention est avantageux par rapport à des vaccins courants inactivés ou vivants atténués, la mise à jour du vaccin ne nécessitant que le remplacement de la séquence codante par le nouveau virus.

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