Dna vaccines against hantavirus infections

Details Dna vaccines against hantavirus infections Dna vaccines against hantavirus infections

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01) A61K 31/7088 (2006.01) A61K 39/12 (2006.01) A61K 39/395 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01) C07K 14/175 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2485348

In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.

Cette invention concerne des vaccins protecteurs à ADN dirigés contre l'infection avec des hantavirus à HFRS et à HPS-associés. Les vaccins ont été construits par sous-clonage de l'ADNc représentant le milieu (M) (codant pour les glycoprotéines G1 et G2) dans le vecteur d'expression d'ADN, pWRG7077. Des animaux vaccinés avec la construction M ont développé une réponse neutralisante d'anticorps. Les expériences passives de transfert montrent que le sérum d'animaux vaccinés, une fois injecté les 4 ième ou 5 ième jours après un test de provocation, protégeaient les animaux de maladie mortelle.

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