Dna vaccines against tumor growth and methods of use thereof

Details Dna vaccines against tumor growth and methods of use thereof Dna vaccines against tumor growth and methods of use thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2519953

A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a DNA construct operably encoding a cancer-associated Inhibitor of Apoptosis-family protein and an immunoactive gene product, such as a cytokine or a ligand for a natural killer cell surface receptor, in a pharmaceutically acceptable carrier. A preferred cytokine is CCL21. Preferred ligands for a natural killer cell surface receptor include human MICA, human MICB, human ULBP1, human ULBP2, and human ULBP3. The cancer-associated Inhibitor of Apoptosis (IAP)-family protein is preferably a survivin protein or livin protein. Method of inhibiting tumor growth by administering the vaccine of the invention to a mammal is also described.

L'invention concerne un vaccin à ADN convenant à l'élicitation d'une réponse immunitaire contre les cellules cancéreuses. Ledit vaccin comprend une construction d'ADN codant opératoire un inhibiteur associé au cancer, du type protéine inhibitrice de l'apoptose (IAP) et un produit génique immunoactif, tel que la cytokine ou un ligand pour un récepteur de surface de cellules tueuses naturelles, dans un véhicule acceptable au plan pharmaceutique. La cytokine préférée est CCL21. Les ligands préférés pour un récepteur de surface de cellules tueuses naturelles sont, entre autres, la MICA humaine, la MICB humaine, l'ULPB1 humaine, l'ULBP2 humaine et l'ULBP3 humaine. L'inhibiteur associé au cancer, du type protéine inhibitrice de l'apoptose est, de préférence, une protéine de type survivine ou livine. La méthode d'inhibition de la croissance tumorale par l'administration à un mammifère du vaccin de l'invention est également décrite.

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