Dna vaccines and methods for the prevention of...

A - Human Necessities – 61 – K

Patent

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A61K 31/713 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2716058

Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipeint, as described herein, can induce a donor specific tolerogenic response.

La présente invention concerne des procédés pour prévenir le rejet, retarder la survenue du rejet, ou traiter le rejet, d'une allogreffe à l'aide d'un vaccin ADN. Le vaccin peut comprendre un polynucléotide codant une protéine pro-apoptotique (BAX, par exemple), et/ou un polynucléotide encodant un auto-antigène ou un antigène de donneur (décarboxylase 55 de l'acide glutamique sécrétée, par exemple). Comme décrit dans l'invention, l'administration de l'un des vaccins ADN à un patient transplanté, peut induire une réponse tolérogénique spécifique au donneur.

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