C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2547079
The present invention is related to recombinant constructs encoding active fragments of HSP60 which are effective in treating T cell-mediated inflammatory autoimmune diseases by DNA vaccines. The HSP60 fragments of the present invention are identified by their ability to react with T cells isolated from an animal vaccinated with DNA constructs encoding HSP70 to induce Th2/3 T-cell responses.
L'invention concerne des constructions de recombinaison codant pour des fragments actifs de HSP60 qui sont efficaces pour traiter les maladies auto-immunes inflammatoires induites par les lymphocytes T au moyen de vaccins d'ADN. Les fragments HSP60 de l'invention sont identifiés par leur aptitude à réagir avec des lymphocytes T isolés provenant d'un animal vacciné au moyen de constructions d'ADN codant pour HSP70 afin d'induire des réponses des lymphocytes T Th2/3.
Cohen Irun R.
Quintana Francisco
Ridout & Maybee Llp
Yeda Research & Development Co. Ltd.
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