Dna vaccines for pets and sport animals

Details Dna vaccines for pets and sport animals Dna vaccines for pets and sport animals

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 39/12 (2006.01) A61K 39/155 (2006.01) A61K 39/175 (2006.01) A61K 39/245 (2006.01) A61K 39/265 (2006.01) A61K 39/27 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07K 14/535 (2006.01) C12N 15/27 (2006.01) C12N 15/38 (2006.01)

Patent

CA 2375320

The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.

L'invention a pour objet l'amélioration de l'efficacité et de la protection induite par la vaccination ADN contre les virus de la famille des Paramyxoviridae et contre les virus herpès, chez les animaux de compagnie et de sport. L'amélioration de la vaccination ADN se fait soit par la formulation du vaccin avec un lipide cationique contenant un sel d'ammonium quaternaire, le DMRIE, soit en des modifications dans la séquence nucléotidique codant pour l'antigène d'intérêt notamment des délétions du fragment de la séquence nucléotidique codant pour le domaine transmembranaire de l'antigène d'intérêt, et/ou des insertions d'introns et/ou des insertions de séquences nucléotidiques codant pour des peptides signaux, soit en l'addition de GM-CSF, soit en leurs combinaisons. Les vaccins ainsi obtenus.

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