Dnas and processes for their preparation, novel plasmids...

Details Dnas and processes for their preparation, novel plasmids... Dnas and processes for their preparation, novel plasmids...

C - Chemistry, Metallurgy

12

N

167/103.2, 195/1

C12N 15/62 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) C07K 14/525 (2006.01) C07K 14/575 (2006.01) C07K 19/00 (2006.01) C12N 15/16 (2006.01) C12N 15/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340244

Anti-tumor polypeptides represented by the amino sequence: (The amino acid sequence of TH.beta.4)-Asp-Pro-X-(the amino acid sequence corresponding to the base sequence constructed by linking guanine with the beginning of the base sequence of the fourth exon of TNF-.alpha.) wherein X is a part of the linkage or represents any of the following amino acid sequences: 1) Val-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala- His-Val-Val; 2) Val-Arg-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val- Ala-His-Val-Val; 3) Val-Lys-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val- Ala-His-Val-Val; 4) Val-Arg-Ser-Ser-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val- Ala-His-Val-Val; and 5) Val-Arg-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val- Ala-His-Val-Val; and, novel DNAs encoding them, processes for their preparation, and anti-tumor agents comprising them are disclosed.

595536

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