Dock-and-lock (dnl) vaccines for cancer therapy

Details Dock-and-lock (dnl) vaccines for cancer therapy Dock-and-lock (dnl) vaccines for cancer therapy

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) A61K 51/00 (2006.01)

Patent

CA 2734265

The present invention concerns methods and compositions for forming anti- cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprises an antibody moiety that binds to dendritic cells, such as an anti-CD74 antibody or antigen-binding fragment thereof, attached to an AD (anchoring domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, wherein two copies of the DDD moiety form a dimer that binds to the AD moiety, resulting in the formation of the DNL complex. The anti--cancer vaccine DNL complex is capable of inducing an immune response against xenoantigen expressing cancer cells, such as CD138 neg CD20+ MM stem cells, and inducing apoptosis of and inhibiting the growth of or eliminating the cancer cells.

La présente invention porte sur des procédés et des compositions pour former des complexes DNL de vaccin anti-cancer à l'aide de la technologie « dock-and-lock ». Dans des modes de réalisation préférés, le complexe DNL de vaccin anticancéreux comprend une fraction danticorps qui se lie à des cellules dendritiques, comme un anticorps anti-CD74 ou un fragment de liaison à un antigène de celui-ci, fixée à une fraction AD (domaine d'ancrage) et un xénoantigène, tel que CD20, fixé à une fraction DDD (domaine de dimérisation et d'ancrage), deux copies de la fraction DDD formant un dimère qui se lie à la fraction AD, conduisant à la formation du complexe DNL. Le complexe DNL de vaccin anticancéreux est capable d'induire une réponse immunitaire contre des cellules cancéreuses exprimant un xénoantigène, telles que des cellules souches CD138negCD20+ MM, et d'induire l'apoptose et d'inhiber la croissance ou d'éliminer les cellules cancéreuses.

Affiliated with

Also associated with

Rating

Dock-and-lock (dnl) vaccines for cancer therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dock-and-lock (dnl) vaccines for cancer therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dock-and-lock (dnl) vaccines for cancer therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2050901