C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/64 (2006.01) C07H 21/04 (2006.01) C12N 1/18 (2006.01) C12N 9/10 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2585235
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an .omega.-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
L'invention concerne une souche modifiée de levure oléagineuse, Yarrowia lipolytica, capable de produire une quantité supérieure à 5,6 % d'acide docosahexanoïque (DHA, un acide gras ?-3 polyinsaturaté) de la partie totale de l'huile. Ladite souche comprend de nombreux gènes exprimant des désaturases hétérologues, des élongases et des acyltransférases, et comprend éventuellement de nombreuses neutralisations de désaturases et d'acyltransférases d'origine, ce qui permet la synthèse et une accumulation élevée de DHA. L'invention concerne, en outre, les cellules hôtes de production ainsi que des procédés pour produire du DHA dans les cellules hôtes.
Damude Howard G.
Gillies Peter John
Macool Daniel Joseph
Picataggio Stephen K.
Ragghianti James John
E.i. Du Pont de Nemours And Company
Torys Llp
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