C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/140,
C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/26 (2006.01) C12P 21/08 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2023894
A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine im- munoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin kappa chain; a gene fragment which com- prises a DNA sequence coding for the constant region of canine immunoglobulin gamma chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-dog chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a canine immunoglobulin wherein the latter gene fragment; a polypeptide of a mouse-dog chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule cording for an amino acid sequence of the mouse-dog chimeric antibody is incorporated; a dog-mouse heterohybridoma which produces canine immunoglobulin; and a process for preparing a canine im- munoglobulin gene.
Eda Yasuyuki
Kimachi Kazuhiko
Maeda Hiroaki
Ono Yoichi
Tokiyoshi Sachio
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
LandOfFree
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