C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 38/05 (2006.01) A61P 35/00 (2006.01) C07K 5/02 (2006.01) C07K 5/027 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2453987
The present invention relates to new compounds of formula I, having an anti- tumor activity, wherein R1, R2, R3, R4, R5 and n are as defined in the description and the claims and pharmaceutical acceptable salts thereof. The present invention concerns also pharmaceutical composition comprising compounds of formula (I), the use of compounds of formula (I) for the preparation of medicaments and process for the preparation of compounds (I).
L'invention concerne de nouveaux composés de la formule (I) qui ont une activité antitumorale, dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et n sont tels que définis dans le descriptif et les revendications, ainsi que des sels de ces composés pharmaceutiquement acceptables. L'invention concerne également une composition pharmaceutique renfermant des composés de la formule (I), l'utilisation de ces composés en vue de préparer des médicaments, ainsi que le processus de préparation des composés de la formule (I).
Fujii Toshihiko
Okada Takehiro
Taniguchi Mikio
Watanabe Fumio
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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