Domain-modified constant region antibodies

Details Domain-modified constant region antibodies Domain-modified constant region antibodies

C - Chemistry, Metallurgy

12

N

195/1.1, 195/1.2

C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 1340863

An antibody having at least one binding site region and a domain-modified constant region is provided wherein the domain-modified constant region is a substitution, duplication, or deletion of substantially all of the amino acids of at least one of the domains of the constant region. The functional properties of the domain-modified constant region antibodies are altered to enhance the desired biological functions for a particular application. DNA sequences encoding constructs expressing domain-modified constant region antibody heavy chains and cells expressing domain-modified constant region antibodies are also provided.

590118

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