C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/415 (2006.01) A01H 1/00 (2006.01) A01H 5/00 (2006.01) A01N 3/00 (2006.01) C12N 15/09 (2006.01) C12N 15/29 (2006.01) C12N 15/82 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2619383
Disclosed are mutant CDK inhibitor (CKI) polypeptides having dominant negative antagonist activity against wild-type CKI proteins, as well as related compositions, including nucleic acids and vectors encoding the mutant CKI polypeptides and transformed host cells and transgenic plants comprising such nucleic acids and vectors. Also disclosed are related methods for using the mutant proteins to modulate cell division in cells, particularly plant cells
La présente invention a trait à des polypeptides inhibiteurs de CDK (CKI) mutants présentant une activité antagoniste négative dominante contre des protéines CKI de type sauvage, ainsi qu'à des compositions associées. Ces polypeptides comprennent des acides nucléiques et des vecteurs codant pour les polypeptides CKI mutants et des cellules hôtes transformées et des végétaux transgéniques comportant de tels acides nucléiques et vecteurs. L'invention a également trait à des procédés pour l'utilisation des protéines mutantes pour la modulation de la division cellulaire dans des cellules, notamment des cellules végétales.
Derocher Jay
Olivier Paul
Gowling Lafleur Henderson Llp
Targeted Growth Inc.
LandOfFree
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