Dominant negative wnt2 compositions and methods of use

Details Dominant negative wnt2 compositions and methods of use Dominant negative wnt2 compositions and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A01N 37/18 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2748716

The present disclosure provides compositions, pharmaceutical preparations, kits and methods for inhibiting cell proliferation by contacting a cell expressing Fzd8 with a truncated Wnt2 polypeptide which acts as a dominant negative inhibitor of Fzd8 signaling. The present disclosure provides compositions, kits and methods for the detection of cancer by determining the level of Fzd8 and/or Wnt2 expression in a cell.

La présente invention porte sur des compositions, des préparations pharmaceutiques, des coffrets et des procédés pour inhiber la prolifération cellulaire par la mise en contact d'une cellule exprimant Fzd8 avec un polypeptide Wnt2 tronqué qui sert d'inhibiteur dominant négatif de la signalisation de Fzd8. la présente invention porte sur des compositions, des trousses et des procédés pour la détection d'un cancer par la détermination du taux de Fzd8 et/ou de l'expression de Wnt2 dans une cellule.

Affiliated with

Also associated with

Rating

Dominant negative wnt2 compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dominant negative wnt2 compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dominant negative wnt2 compositions and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1908925