Dopamine and serotonin transporter ligands and imaging agents

Details Dopamine and serotonin transporter ligands and imaging agents Dopamine and serotonin transporter ligands and imaging agents

C - Chemistry, Metallurgy

07

F

C07F 13/00 (2006.01) A61K 51/04 (2006.01) C07D 451/02 (2006.01)

Patent

CA 2233173

This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium having the formula (See formula I) with X, Z, N, and Q being specifically defined herein. These compounds are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have utility, inter alia, as imaging agents for CNS receptors. Methods of using these novel compounds as imaging agents are presented, as are intermediates and methods for making these novel compounds.

La présente invention concerne une série de nouveaux dérivés à base de tropane complexés avec du technétium ou du rhénium, qui sont spécifiques des récepteurs du système nerveux central, notamment des récepteurs de la dopamine et de la sérotonine. Ces composés sont utiles, entre autres, comme agents d'imagerie pour les récepteurs du système nerveux central. L'invention décrit des procédés d'utilisation de ces nouveaux composés comme agents d'imagerie, ainsi que des intermédiaires et des procédés pour fabriquer ces nouveaux composés.

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