Dopamine receptor ligands and imaging agents

Details Dopamine receptor ligands and imaging agents Dopamine receptor ligands and imaging agents

C - Chemistry, Metallurgy

07

D

167/47, 260/241.

C07D 223/16 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07F 3/12 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2011738

Novel CNS dopamine D-1 receptors, such as the compound ()-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[125I]iodophenyl)- 1H-3-benzazepine-7-ol, are disclosed. These compounds are useful as imaging agents for D-1 receptors in the human brain and exhibit good brain retention and in vivo stability. The invention also extends to a process for preparing the novel compounds, and to novel intermediates useful in the preparation of the novel compounds.

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