Dopaminergic neuronal survival-promoting factors and uses...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) A61P 25/00 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2383076

The invention features a pharmaceutical composition that includes arginine- rich protein and a pharmaceutically-acceptable excipient. The invention also features methods for treatment of a neurodegenerative disease, methods for improving neuronal survival during or following cell transplantation, methods for production of neurons for transplantation, and methods for identifying compounds that modulate or mimic arginine-rich protein's biological activity.

Cette invention a trait à une composition pharmaceutique contenant une protéine riche en arginine ainsi qu'un excipient acceptable du point de vue pharmaceutique. Elle concerne également des méthodes de traitement de maladies neurodégénératives, des techniques permettant de renforcer la survie de neurones lors de transplantation cellulaire ou à la suite de celle-ci, des procédés de production de neurones aux fins de transplantation ainsi que des techniques permettant d'identifier des composés modulant ou mimant l'activité biologique d'une protéine riche en arginine.

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