Dopaminergic neuronal survival-promoting factors and uses...

Details Dopaminergic neuronal survival-promoting factors and uses... Dopaminergic neuronal survival-promoting factors and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 5/06 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2441740

In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a pharmaceutical composition that includes MANF and a pharmaceutically-acceptable excipient, methods for treatment of a neurodegenerative disease, methods for improving dopaminergic neuronal survival during or following cell transplantation, methods for production of neurons for transplantation, and methods for identifying compounds that modulate or mimic MANF's biological activity.

L'invention concerne de façon générale des facteurs MANF sensiblement purifiés ainsi que des acides nucléiques sensiblement purifiés codant ceux-ci. Par ailleurs, l'invention concerne une composition pharmaceutique qui contient des facteurs MANF ainsi qu'un excipient acceptable sur le plan pharmaceutique, des méthodes de traitement d'une maladie neurodégénérative, des méthodes d'amélioration de la survie des neurones dopaminergiques pendant ou après une greffe de cellules, des méthodes de production de neurones pour une greffe, ainsi que des méthodes d'identification de composés qui modulent ou imitent l'activité biologique des facteurs MANF.

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