Dosage form for coadministering drug and percutaneous...

Details Dosage form for coadministering drug and percutaneous... Dosage form for coadministering drug and percutaneous...

A - Human Necessities

61

M

128/104, 167/159

A61M 37/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 1166961

ARC 742 DOSAGE FORM FOR COADMINISTERING DRUG AND PERCUTANEOUS ABSORPTION ENHANCER Abstract A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed at a therapeutically effective rate. A preferred embodiment delivers estradiol and employs ethanol as an enhancer, the ethanol delivery rate being about 100-800 mcg/hr/cm2 of skin surface. 4:0130:3P1CMG 12/18/81

395641

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