Dosage forms and methods for providing effective reboxetine...

Details Dosage forms and methods for providing effective reboxetine... Dosage forms and methods for providing effective reboxetine...

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 9/00 (2006.01) A61K 9/22 (2006.01)

Patent

CA 2384624

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.

La présente invention concerne des formes et procédés pharmaceutiques permettant d'assurer une libération prolongée de reboxetine. Les formes pharmaceutiques à libération prolongée de l'invention fournissent des concentrations moyennes de reboxetine à l'état stationnaire dans le plasma thérapeutiquement efficaces en étant administrées une fois par jour. Ce schéma posologique d'une prise quotidienne n'entraîne l'apparition d'une concentration maximale de reboxetine dans le plasma qu'une fois par 24 heures. En outre, le pic de concentration de reboxetine dans le plasma se produit quelque temps après l'administration de la dose et il possède une amplitude moindre que le pic de concentration de reboxetine dans le plasma observé après l'administration de formes pharmaceutiques de reboxetine à libération immédiate.

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