Dosage forms and methods of treatment using a tyrosine...

Details Dosage forms and methods of treatment using a tyrosine... Dosage forms and methods of treatment using a tyrosine...

A - Human Necessities

61

K

A61K 31/5377 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2622870

This invention provides dosage forms of a compound of formula 1, 5-[(Z)-(5- fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidene) methyl]-N-[(2S)-2- hydroxy-3- morpholin -4- ylpropyl] -2,4- dimethyl-1H- pyrrole-3- carboxamide, or pharmaceutically acceptable salts or solvates thereof. The invention further provides methods of treating abnormal cell growth in a patient, such as cancers, by administering the dosage forms to the patient. The invention further provides methods of treating an angiogenesis- or VEGF- related ophthalmic disorder in a patient, by administering the dosage form to the patient.

présente invention a trait à des formes de dosage d'un composé de formule 1, 5-[(Z)-(5-fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidène) méthyl]-N-[(2S)-2- hydroxy-3- morpholin -4- ylpropyl] -2,4- diméthyl-1H- pyrrole-3- carboxamide, ou des sels ou solvates pharmaceutiquement acceptables de celui-ci. L'invention a également trait à des procédés de traitement de la croissance cellulaire anormale chez un patient, tels que des cancers, par l'administration des formes de dosage au patient. L'invention a trait en outre à des procédés de traitement de trouble ophtalmique associé à l'angiogenèse ou au facteur de croissance endothéliale chez un patient, par l'administration de la forme de dosage au patient.

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