Dosage forms comprising a cetp inhibitor and an hmg-coa...

Details Dosage forms comprising a cetp inhibitor and an hmg-coa... Dosage forms comprising a cetp inhibitor and an hmg-coa...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 31/00 (2006.01) A61K 31/4706 (2006.01) A61K 45/06 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2509688

A dosage form comprises (1) a solid amorphous dispersion comprising a cholesteryl ester transfer protein inhibitor and an acidic concentrationenhancing polymer and (2), an HMG-CoA reductase inhibitor. The solid amorphous dispersion and the HMG-CoA reductase inhibitor are combined in the dosage form so that the solid amorphous dispersion and the HMG-CoA reductase inhibitor are substantially separate from one another in the dosage form.

Cette invention concerne une forme posologique composée (1) d'une dispersion amorphe solide qui comprend un inhibiteur de la protéine de transfert de cholestéryl ester et un polymère d'accentuation de la concentration acide et 2), un inhibiteur de la HMG-COA réductase. La dispersion amorphe solide et l'inhibiteur de la HMG-COA réductase sont combinés dans la forme posologique de telle sorte que ces deux constituants soient sensiblement distincts l'un de l'autre.

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