Dosage forms comprising porous particles

Details Dosage forms comprising porous particles Dosage forms comprising porous particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/26 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2355860

A dosage form comprising a plurality of particles having interior pores and a liquid, active agent formulation in the pores, the particles being compactable and adapted to retain substantially all of the liquid active agent formulation within the pores during the compacting process, is described. The dosage forms may be in the forms of unitary oral forms for immediate release of active agent, prolonged delivery forms, or controlled delivery forms. All forms involve certain absorbent materials having prescribed characteristics, particularly spray dried calcium hydrogen phosphate and magnesium aluminometasilicate.

L'invention concerne une forme posologique comprenant plusieurs particules possédant des pores intérieurs, lesquels contiennent une formule d'agent actif liquide, les particules étant compactables et conçues pour conserver sensiblement toute la formule d'agent actif liquide, pendant le processus de compactage. Les formes posologiques peuvent se présenter sous forme de formes orales unitaires à libération immédiate, de formes à libération prolongée ou à libération lente. Dans toutes les formes impliquées, on utilise certains matériaux absorbants présentant des caractéristiques spécifiques, notamment du phosphate d'hydrogène de calcium et de l'aluminométasilicate séchés par atomisation.

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