Dosage forms comprising separate portions of r- and...

Details Dosage forms comprising separate portions of r- and... Dosage forms comprising separate portions of r- and...

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/70 (2006.01) A61K 31/135 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2285407

A pharmaceutical dosage form comprises, in one portion thereof, a substantially single (+)-enantiomer of a chiral drug other than verapamil and, in another separate portion thereof, a substantially single (-)- enantiomer of the drug, wherein, in use, the different enantiomers are released at different rates from the dosage form. The dosage form is useful for administration of chiral drugs where both enantiomers have a valid pharmacological input, and where a clinical benefit may be realised by controllling the release rates of those enantiomers. Examples of such drugs include, in particular, tramadol and warfarin.

L'invention concerne une forme galénique pharmaceutique comprenant, dans une partie, un seul énantiomère-(+) d'un médicament chiral autre que le vérapamil et, dans une autre partie séparée, un seul énantiomère-(-) de ce médicament. Lors de l'utilisation, les différents énantiomères sont libérés de la forme galénique à des vitesses différentes. Cette forme galénique est utile pour administrer des médicaments chiraux dans lesquels les deux énantiomères ont un effet pharmacologique actif et qui peuvent présenter un avantage clinique par la régulation des vitesses de libération de ces énantiomères. On peut citer à titre d'exemple de ces médicaments, notamment, le tramadol et la warfarine.

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