Dosage forms for administering combinations of drugs

Details Dosage forms for administering combinations of drugs Dosage forms for administering combinations of drugs

A - Human Necessities

61

K

A61K 9/24 (2006.01)

Patent

CA 2644435

The present invention is directed to dosage forms that can be used in therapeutic methods involving the oral co-administration of a combination of at least two drugs, one of which impairs gastrointestinal absorption and one of which does not. The dosage forms are designed so that the drug impairing absorption is not released into the gastrointestinal tract of a patient until after the drugs that do not impair absorption have been released and substantially absorbed. The invention may be used in treatment of migraine using a combination of triptans and NSAlDs or in the treatment of pain using a combination of NSAIDs and opioid analgesics.

La présente invention concerne des formes pharmaceutiques pouvant être utilisées dans le cadre de procédés thérapeutiques basés sur la co-administration orale d'une association composée d'au moins deux médicaments, l'un d'eux inhibant l'absorption gastro-intestinale et l'autre pas. Les formes pharmaceutiques sont conçues de façon à ce que le médicament inhibant l'absorption ne soit libéré dans le tractus gastrointestinal d'un patient qu'après que les médicaments n'inhibant pas l'absorption ont été libérés et largement absorbés. Cette invention peut être utilisée pour le traitement de la migraine, en utilisant une association composée de triptans et d'AINS, ou pour le traitement de la douleur, en utilisant une association composée d'AINS et d'analgésiques opioïdes.

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