Dosage forms with improved bioavailability

Details Dosage forms with improved bioavailability Dosage forms with improved bioavailability

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2618264

A solid dispersion product comprising an effective amount of one or more active ingredients and an effective amount of one or more hydroxypropyl methylcellulose(s), which satisfies the Formula 0.35 > .DELTA.Htr (1) (wherein AHtr represents the endotherm (J/g) accompanying a transition at about 240~ C). The solid dispersion product is used for the manufacture of a dosage form having improved bioavailability of said one or more active ingredients by oral administration to a patient in need thereof.

L'invention concerne un produit à dispersion solide dont le volume effectif compte un ou plusieurs ingrédients actifs ainsi que une ou plusieurs méthylcelluloses hydroxypropyliques, en conformité avec la Formule 0,35 > DHtr (1) (où AHtr représente l'endotherme (J/g) qui accompagne une transition à environ 240 °C). Le produit à dispersion solide est employé dans la production d'une formule posologique à la biodisponibilité améliorée de ce ou ces ingrédients actifs administrés par voie orale au patient concerné.

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