A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/27 (2006.01) A61K 31/353 (2006.01) A61K 31/40 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2351347
Acetylcholinesterase inhibitors are of use for treating a variety of diseases and conditions including Alzheimer's disease. They also affect circadian rhythms. In order to optimize the use of such compounds, the present invention provides dosage forms and methods of treatment wherein an effective amount of a centrally-acting acetylcholinesterase inhibitor is formulated so as to delay its activity for a predetermined period. Suitable acetylcholinesterase inibitors include galanthamine, lycoramine, analogs thereof and rivastigmine.
Les inhibiteurs de l'acétylcholinestérase sont utilisés pour traiter diverses maladies et états notamment la maladie d'Alzheimer. Ils ont aussi un effet sur les rythmes nycthéméraux. Dans le but d'optimiser l'utilisation de ces composés, la présente invention fournit des formules de dosage et des méthodes de traitement dans lesquelles une dose efficace d'inhibiteurs de l'acétylcholinestérase agissant de façon centrale est formulée de sorte qu'elle retarde son action pendant une période prédéterminée. Parmi les inhibiteurs de l'acétylcholinestérase adaptés, citons la galanthamine, la lycoramine, leurs analogues et la rivastigmine.
Davis Bonnie
Marks & Clerk
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