Dosage regimen of an s1p receptor agonist

Details Dosage regimen of an s1p receptor agonist Dosage regimen of an s1p receptor agonist

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2589265

S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial 3 to 6 days of treatment the daily dosage is raised so that in total the R-fold (R being the accumulation factor) standard daily dosage is administered and thereafter continued at the standard daily dosage or at a daily dosage lower than the standard daily dosage.

Selon l'invention, des modulateurs ou agonistes du récepteur S1P sont administrés conformément à une posologie selon laquelle, au cours des 3 à 6 jours initiaux de traitement, la dose quotidienne est augmentée si bien qu'au total, la dose quotidienne normale multipliée par R (R étant le facteur d'accumulation) est administrée, et le traitement poursuivi ensuite à ladite dose quotidienne normale ou à une dose quotidienne inférieure à la dose quotidienne normale.

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