Dosing form for a polymer support, use of said dosing form...

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01) B65D 83/04 (2006.01) C07K 1/04 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2402584

A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional groups are compressed into tablets after pre-treatment with an aprotic organic solvent.

Forme de dosage pour support polymère utilisée dans la synthèse chimique, dans un milieu de solvant comprenant une quantité de poids fixe de billes d'un polymère contenant des groupes fonctionnels, ledit polymère étant insoluble dans le solvant lorsqu'on effectue cette synthèse, qui se présente sous forme de comprimés de poids et de composition sensiblement égaux, lesdites billes polymères restant sensiblement intactes et étant libérées telles quelles lorsque les comprimés se désintègrent dans le solvant. La forme s'utilise dans la synthèse traditionnelle, la synthèse parallèle, la synthèse mixe ou la synthèse séparée et/ou en chimie combinatoire. Selon le procédé de fabrication de ladite forme de dosage, les billes polymères comportant des groupes fonctionnels sont transformées en comprimés après prétraitement avec un solvant organique aprotique.

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