Double-stranded locked nucleic acid compositions

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/00 (2006.01) A61K 31/713 (2006.01) A61K 39/39 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2680060

Immunostimulatory agents, including nucleic acids having one or more than one locked nucleic acid (LNA) nucleosides are provided. The nucleic acids may further comprise CpG motifs. The nucleic acids may be double stranded, and may comprise dsRNA.

La présente invention concerne des agents immunostimulateurs, y compris des acides nucléiques présentant un ou plus d'un nucléoside d'acide nucléique verrouillé (LNA). Les acides nucléiques peuvent comprendre en outre des motifs CpG. Les acides nucléiques peuvent être double brin et ils peuvent comprendre du dbARN.

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