Double-stranded oligonucleotides

Details Double-stranded oligonucleotides Double-stranded oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 1/04 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2475003

Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.

Selon cette invention, des séquences antisens, comprenant des compositions d'ARN interférents bicaténaires, possèdent des propriétés améliorées par rapport à celles appartenant à la technique antérieure. Cette invention concerne des compositions d'oligomères antisens optimisées et des méthodes de préparation et d'utilisation de ces compositions dans des systèmes in vitro et in vivo, autrement dit des systèmes thérapeutiques. Cette invention concerne également des méthodes de préparation et d'utilisation de ces compositions d'oligomères antisens améliorées.

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