C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 47/48 (2006.01) A61P 5/06 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01)
Patent
CA 2720306
The growth hormone with high biological activity modified by the double- stranded polyethylene glycol at a single site and the preparation method thereof are provided. The PEGylated growth hormone has a higher biological activity and a longer half- life than the unmodified growth hormone. The composition comprising the PEGylated growth hormone is useful in the treatment of the growth or development disorder such as growth hormone deficiency, Turner syndrome etc..
L'invention porte sur des hormones de croissance mono-modifiées par polyéthylèneglycol double brin et sur leurs procédés de préparation. L'hormone de croissance pégylée a une activité biologique supérieure et une plus longue durée de vie, etc. par comparaison avec l'hormone de croissance non modifiée. La composition comprenant l'hormone de croissance pégylée peut être utilisée pour traiter un trouble de la croissance ou du développement comme une carence en hormone de croissance, le syndrome de Turner, etc.
Liao Xiaojin
Lin Huihuang
Lu Qingsong
Shen Shiye
Sun Li
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biosteed Gene Expression Tech. Co. Ltd.
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