Double-stranded polynucleotide

Details Double-stranded polynucleotide Double-stranded polynucleotide

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2729762

It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. The present invention provides a double-stranded polynucleotide consisting of sense and antisense strands consisting of polynucleotides comprising a nucleotide unit of DNAs and 2'-O-methyl RNAs alternately combined.

L'invention porte sur un polynucléotide double brin qui est stable à l'encontre d'une ribonucléase et a une activité d'interférence avec l'ARN; et autres. De façon spécifique, l'invention porte sur un polynucléotide double brin composé d'un brin sens et d'un brin anti-sens. Le polynucléotide double brin comprend un polynucléotide contenant une unité nucléotidique comprenant une combinaison alternée d'ADN ou de 2'-O-méthyl ARN.

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