Double-stranded ribonucleic acid constructs and methods for...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2479409

The invention relates to constructs and methods for the regulation of gene expression of at least two endogenous target genes by introduction of an at least partly double-stranded ribonucleic acid molecule into a eukaryotic cell or a eukaryotic organism, whereby the ribonucleic acid molecule comprises at least two ribonucleotide sequence sections which are homologous with various genes of the eukaryotic cell.

La présente invention concerne des produits de synthèse et un procédé de régulation de l'expression génique d'au moins deux gènes cibles endogènes par introduction d'une molécule d'acide ribonucléique au moins partiellement à double brin dans une cellule eucaryote ou un organisme eucaryote. La molécule d'acide ribonucléique contient au moins deux segments de séquence ribonucléotidique qui sont homologues de gènes différents de la cellule eucaryote.

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