Double-stranded rna-mediated gene suppression

Details Double-stranded rna-mediated gene suppression Double-stranded rna-mediated gene suppression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C12M 3/00 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2433680

The present invention relates to methods for modifying gene expression and in particular to methods for controlling gene expression in eukaryotic cells using double-stranded RNA (dsRNA), and to eukaryotic cell lines in which gene expression has been altered using the method. The invention also relates to compositions suitable for controlling gene expression and to methods of treatment which utilise such compositions.

La présente invention concerne des méthodes de modification de l'expression d'un gène et en particulier des méthodes de régulation de l'expression d'un gène dans des cellules eucaryotes à l'aide d'ARN bicaténaire (ARNbc), et des lignées de cellules eucaryotes dans lesquelles l'expression d'un gène a été modifiée selon la méthode. L'invention concerne également des compositions aptes à la régulation de l'expression d'un gène ainsi que des méthodes de traitement lesquelles utilisent ces compositions.

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