Double-stranded rna receptor (dsrna-r) and methods relating...

Details Double-stranded rna receptor (dsrna-r) and methods relating... Double-stranded rna receptor (dsrna-r) and methods relating...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2390031

The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response and the methods of identifying compounds which bind to and/or modulate dsRNA-R.

L'invention concerne des molécules d'acides nucléiques et des polypeptides codant un récepteur d'ARN double brin (dsRNA-R). Le dsRNA-R contient un domaine THD, interagit avec la protéine d'adaptation MyD88 et peut se lier au dsRNA. La présente invention concerne aussi des anticorps dirigés contre dsRNA-R, des procédés pour moduler une réponse immunitaire et des procédés d'identification des composés qui se lient à dsRNA-R et/ou le modulent.

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