Double transfectants of mhc genes as cellular vaccines for...

Details Double transfectants of mhc genes as cellular vaccines for... Double transfectants of mhc genes as cellular vaccines for...

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2092674

A B S T R A C T Double Transfectants of MHC Genes as Cellular Vaccines for Immunoprevention of Tumor Metastasis The present invention relates to anti-tumor vaccines comprising at least one type of tumor cell into each of which at least two genes encoding MHC proteins of different haplotypes have been inserted, or naturally expressed, said genes being expressed in said tumor cells and wherein at least one of said MHC proteins has the same haplotype as a haplotype of the individual to be vaccinated. The invention furthermore relates to a method of treating a patient suffering from a tumorous disease comprising administering a vaccine of the invention and to the use of a vaccine of the invention for the preparation of an anti-tumor vaccine.

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