A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) A61P 31/18 (2006.01) A61P 31/22 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2283684
Disclosed is a method of down-regulating the expression of a gene in an animal, wherein an oligonucleotide complementary to the gene is colorectally administered to an animal. Also disclosed is a method for introducing an intact oligonucleotide into a mammal by colorectal administration, whereby the oligonucleotide is present in intact form in the systemic plasma of the mammal at least four hours following administration.
L'invention concerne une méthode de rétro-régulation de l'expression génique chez un animal, un oligonucléotide complémentaire au gène étant administrée par voie colo-rectale à l'animal. L'invention concerne également une méthode d'introduction d'un oligonucléotide intact dans un animal par voie colo-rectale, l'oligonucléotide étant retrouvé intact dans le plasma systémique du mammifère au moins quatre heures après administration.
Agrawal Sudhir
Zhang Ruiwen
Hybridon Inc.
Idera Pharmaceuticals Inc.
Mbm Intellectual Property Law Llp
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