Downregulation of allergen-specific immune response

Details Downregulation of allergen-specific immune response Downregulation of allergen-specific immune response

C - Chemistry, Metallurgy

07

K

C07K 14/725 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2161316

Synthetic peptides are provided for effecting immunotherapy. The peptides have an amino acid sequence comprising at least a portion of the CDR3 region of a T-cell receptor and capable of eliciting a T-cell response, particularly an amino acid sequence encoded by a nucleotide sequence comprising the J-gene of the .alpha.-chain and/or .beta.-chain of the TCR. The peptides are particularly useful in suppressing an immune response to an antigen, particularly an allergenic antigen.

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