Dph2 gene deletion mutant and uses thereof

Details Dph2 gene deletion mutant and uses thereof Dph2 gene deletion mutant and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) A61P 39/00 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 7/01 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2655565

Diphtheria and Pseudomonas infections are very common worldwide. The toxins involved in the pathogenesis of those diseases act by inactivating the elongation factor-2 (EF-2), therefore blocking protein synthesis and leading to cell death. Diphthamide formation on EF-2 is a prerequisite step in the inactivation of EF-2, and Dph proteins have been identified as modulating this process. The present application concerns Dph2 deletion mutant genes and proteins and their uses in vitro and in vivo.

La diphtérie et les infections par Pseudomonas sont très courantes dans le monde entier. Les toxines mises en jeu dans la pathogenèse de ces maladies agissent par inactivation du facteur d'élongation 2 (EF-2), bloquant par conséquent la synthèse protéique et conduisant à la mort cellulaire. La formation de diphtamide sur EF-2 est une étape préalable dans l'inactivation de EF-2, et les protéines Dph ont été identifiées comme modulant ce procédé. La présente invention concerne des gènes mutants par la délétion de Dph2 et des protéines et leurs utilisations in vitro et in vivo.

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