Dpyd gene variants and use thereof

Details Dpyd gene variants and use thereof Dpyd gene variants and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 9/02 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2655497

Variants in DPYD gene are disclosed which can result in abnormal synthesis of DPD proteins and alteration of DPD activities. The invention provides methods for detecting the newly discovered genetic variants. The DPD genetic variants of the invention can be used as biomarkers in predicting toxicity to 5-FU and other drugs metabolized by the DPD enzyme.

La présente invention concerne des variantes du gène DPYD qui peuvent provoquer des anomalies dans la synthèse des protéines DPD et une modification des activités DPD. L'invention concerne des procédés de détection des variantes génétiques nouvellement découvertes. Les variantes génétiques de DPD selon l'invention peuvent être utilisées en tant que bio-marqueurs pour prédire la toxicité envers 5-FU et d'autres médicaments métabolisés par l'enzyme DPD.

Affiliated with

Also associated with

Rating

Dpyd gene variants and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dpyd gene variants and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dpyd gene variants and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1526544