Dr5 antibodies and uses thereof

Details Dr5 antibodies and uses thereof Dr5 antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01)

Patent

CA 2564129

The invention provides antibodies which specifically bind to DR5 receptor. The anti-DR5 antibodies optionally contain CDR sequences identified using phage- display techniques. The DR5 antibodies can be used, for example, in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptors is desired, including cancer and immune-related conditions.

L'invention concerne des anticorps qui se lient de façon spécifique à un récepteur DR5. Les anticorps anti DR5 contiennent éventuellement des séquences CDR identifiées au moyen de techniques d'expression phagique. Les anticorps DR5 peuvent être utilisés, par exemple, dans des procédés dans lesquels une modulation des activités biologiques d'Apo-2L et/ou de récepteurs Apo-2L est souhaitée, notamment dans des cancers et des conditions liées à l'immunité.

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