Dr6 antagonists and uses thereof in treating neurological...

Details Dr6 antagonists and uses thereof in treating neurological... Dr6 antagonists and uses thereof in treating neurological...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2671903

Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue.

Cette invention concerne des procédés et des compositions comprenant des antagonistes du DR6 à utiliser dans le traitement des troubles neurologiques, y compris la maladie d'Alzheimer. Les antagonistes du DR6 comprennent des anticorps anti-APP, des anticorps anti-DR6, des immunoadhésines DR6 et des variantes du DR6 (et leurs protéines de fusion) qui stimulent la croissance, la régénération ou la survie des cellules neuronales ou du tissu neuronal chez les mammifères.

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