Drivatives of 1h, 3h-prorrolo [1,2-c] thiazole, their...

Details Drivatives of 1h, 3h-prorrolo [1,2-c] thiazole, their... Drivatives of 1h, 3h-prorrolo [1,2-c] thiazole, their...

C - Chemistry, Metallurgy

07

D

260/277.3, 260/2

C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1294966

BREVET D'INVENTION NOUVEAUX DERIVES DU lH,3H-PYRRoLo [1,2-c] THIAZOLE, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT RHONE-POULENC SANTE ABREGE Nouveaux dérives de formule (I) dans laquelle R = H, halogène, alcoyle, alcoyloxy, alcoylthio, CF3, NH2, alcoylamino, dialcoylamino, OH, CN, COOH, alcoylsulfinyle, alcoylsulfonyle, sulfamido, alcoylsulfauido, dialcoylsulfamido, carbauoyle, alcoylcar- banoyle, dialcoylcarbamoyle, phénylcarbamoyle, diphénylcarbanoyle, pyridylcarbamoyle, dipyridylcarbamoyle, benzyle, alcoylcarbonyle, C6H5CO, alcoyloxycarbonyle, phénoxycarbonyle, alcoylcarbonyloxy, ben- zoyloxy, alcoylcarbonylamino, benzamido, C6H5, C6H5O ou C6H5S, X = O,S,NH, alcoylimino, phénylimino, benzylimino, SO, SO2, CO, COCH2, CH2CO, CH=CH-CO ou COCH=CH ou bien représente une liaison de valence ou un radical alcoylenne (1 à 4 C) et Ar = phényle, naphtyle, pyridy- le, quinolyle, isoquinolyle, thiényle, benzothiényle, thiéno [3,2-b] thiényle-2 ou thiéno [2,3-b] thiényle-2, ces radicaux étant non substitués ou substitués par un ou plusieurs halogène, alcoyle, alcoyloxy, alcoylthio, CF3, NH2, alcoylamino, dialcoylamino, OH, CN, COOH, alcoylsulfinyle, alcoylsulfonyle, sulfamido, alcoylsulfamido, dialcoylsulfamido, carbamoyle, alcoylcarbamoyle, dialcoylcarbamoyle, phénylcarbamoyle, diphénylcarbamoyle, pyridylcarbamoyle, dipyridyi- carbamoyle, benzyle, alcoylcarbonyle, C6H5CO, alcoyloxycarbonyle, phénoxycarbonyle, alcoylcarbonyloxy, benzoyloxy, alcoylcarbonylamino, benzamido. L'invention concerne les produits racémiques, les énantio- mères purs et leurs mélanges ainsi que les sels pharmaceutiquement acceptables. Image (I) Ces produits sont utiles comme médicaments pour traiter toutes les conditions pathologiques dans lesquelles le PAF-acéther peut être directement ou indirectement incriminé.

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