A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/37 (2006.01)
Patent
CA 2142315
Sufficiently high blood benzopyrone levels cannot be achieved on oral administration of benzo- pyrone. From the point of view of pharmacokinetics and chronic application, the use of benzopyrone as an oint- ment is not optimal because the blood levels thus achievable cannot be controlled. It has now surprisingly been found that benzo- pyrone in a particular formulation as part of a trans- dermal therapeutic system (TDS), after application to the skin, is released to the skin in a constant manner as a function of time and over a longer period owing to the absorption of perspiration, and that constant therapeutically effective blood and tissue levels of benzopyrone are achieved in humans, which levels are a factor of 50 higher than those following the oral ad- ministration of the same doses of benzopyrone.
Cierpka Henning F.
Lutz Jurg
Drossapharm Ag
Swabey Ogilvy Renault
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