B - Operations – Transporting – 02 – C
Patent
B - Operations, Transporting
02
C
B02C 17/14 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2450900
The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterised by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibration and keeping its amplitude constant, produces drug/carrier composites with a constant particle size in which the degree of drug activation increases in proportion to the frequency applied. The invention also includes a vibrational mill suitably modified to perform the process described.
La présente invention concerne un procédé d'activation de médicaments par le broyage à haute énergie du médicament conjointement avec un support pharmaceutique, caractérisé en ce qu'on utilise un broyeur vibratoire équipé de moyens de réglage de la fréquence de vibration. Le procédé, mis en oeuvre par la modification de la fréquence de vibration et le maintien de l'amplitude constante, produit des composites de médicament/support présentant une granulométrie constante dans lesquels le degré d'activation de médicament augmente proportionnellement à la fréquence appliquée. L'invention concerne également un broyeur vibratoire modifié de manière appropriée pour la mise en oeuvre dudit procédé.
Bresciani Massimo
Dobetti Luca
Rabaglia Leonardo
Eurand Pharmaceuticals Ltd.
Marks & Clerk
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