A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61K 31/436 (2006.01) A61K 31/727 (2006.01) A61K 45/06 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2408606
The current invention comprises an approach to solving the clinical problem of restenosis, which involves the administration of combinations of drugs to patients undergoing PTCA or stent implantation. In one embodiment of the invention, an antiproliferative agent such as rapamycin, vincristine or taxol is administered in combination with the antiinflammatory agent, dexamethasone, to patients systemically, either subcutaneously or intravenously. In another embodiment of the invention, the antiproliferative and antiinflammatory agents are bound in a single formulation to the surface of a stent by means of incorporation within either a biodegradable or biostable polymeric coating. Alternatively, such drug combinations could be incorporated into a stent constructed with a grooved reservoir.
L'invention concerne une approche visant à résoudre le problème clinique de la resténose, qui consiste à administrer des combinaisons de médicaments aux patients subissant une ACTP ou une implantation d'extenseur. Selon une variante, on utilise un agent antiprolifératif du type rapamycine, vincristine ou taxol, administré de façon systémique en combinaison avec un anti-inflammatoire, la dexaméthasone, par voie sous-cutanée ou intraveineuse. Selon une autre variante, les agents considérés sont fixés en une formulation unique à la surface d'un extenseur au moyen d'un revêtement polymère incorporé, biodégradable ou biostable. On peut aussi incorporer les combinaisons à un extenseur comportant un réservoir rainuré.
Falotico Robert F.
Kopia Gregory A.
Llanos Gerald H.
Cordis Corporation
Sim & Mcburney
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