Drug combinations useful for prevention of restenosis

A - Human Necessities – 61 – L

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61K 31/436 (2006.01) A61K 31/727 (2006.01) A61K 45/06 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2408606

The current invention comprises an approach to solving the clinical problem of restenosis, which involves the administration of combinations of drugs to patients undergoing PTCA or stent implantation. In one embodiment of the invention, an antiproliferative agent such as rapamycin, vincristine or taxol is administered in combination with the antiinflammatory agent, dexamethasone, to patients systemically, either subcutaneously or intravenously. In another embodiment of the invention, the antiproliferative and antiinflammatory agents are bound in a single formulation to the surface of a stent by means of incorporation within either a biodegradable or biostable polymeric coating. Alternatively, such drug combinations could be incorporated into a stent constructed with a grooved reservoir.

L'invention concerne une approche visant à résoudre le problème clinique de la resténose, qui consiste à administrer des combinaisons de médicaments aux patients subissant une ACTP ou une implantation d'extenseur. Selon une variante, on utilise un agent antiprolifératif du type rapamycine, vincristine ou taxol, administré de façon systémique en combinaison avec un anti-inflammatoire, la dexaméthasone, par voie sous-cutanée ou intraveineuse. Selon une autre variante, les agents considérés sont fixés en une formulation unique à la surface d'un extenseur au moyen d'un revêtement polymère incorporé, biodégradable ou biostable. On peut aussi incorporer les combinaisons à un extenseur comportant un réservoir rainuré.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Drug combinations useful for prevention of restenosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug combinations useful for prevention of restenosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug combinations useful for prevention of restenosis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1593201

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.